Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC IIQLPEIVVV TFA | 99.9% | 1122.40 | 1 MG
IIQLPEIVVV TFA is a specific inhibitor of Drp1-Mff interaction. It can distinguish physiological from pathological fission and block physiological fission, leading to mitochondrial dysfunction. It can be used in the study of Huntington's disease.
- Specific inhibitor of Drp1-Mff interaction
- Distinguishes physiological from pathological fission
- Blocks physiological fission
- Leads to mitochondrial dysfunction
- Used in the study of Huntington's disease
- Purity of 99.91%
- White to off-white solid appearance
- Sequence: Ile-Ile-Gln-Leu-Pro-Glu-Ile-Val-Val-Val
Medchemexpress LLC c(avb6)-DOTA TFA | 98.6% | 1546.65 | 1 MG
c(avb6)-DOTA TFA is a conjugate of the αvβ6 integrin selective peptide ring modified with the DOTA chelator. The Lu(III) complex of c(avb6)-DOTA TFA shows a comparable affinity for αvβ6 integrin (IC50=0.8 nM) and can be utilized as a tumor diagnostic.
- Conjugate of αvβ6 integrin selective peptide ring
- Modified with DOTA chelator
- Lu(III) complex shows comparable affinity for αvβ6 integrin (IC50=0.8 nM)
- Can be utilized as a tumor diagnostic
- Intended for research use only
Medchemexpress LLC Lonodelestat TFA | 906547-89-5 | 99.6% | 1478.73 | 25 MG
Lonodelestat (POL6014) is a potent, orally active, and selective peptide inhibitor of human neutrophil elastase (hNE). It has potential for research related to cystic fibrosis (CF).
- Potent, orally active, and selective peptide inhibitor of human neutrophil elastase.
- Significantly reduced inflammatory processes of acute lung injury in HNE-treated mice.
- Suitable for research related to cystic fibrosis.
- Soluble in H2O: 20 mg/mL (13.53 mM); requires ultrasonic and warming.
- Powder storage: -80°C for 2 years, -20°C for 1 year.
- In solvent storage: -80°C for 6 months, -20°C for 1 month (sealed storage, away from moisture).
![Medchemexpress LLC [D-Lys6]-LH-RH TFA | 1253.41 (free base) | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000397384.png-250.jpg)
Medchemexpress LLC [D-Lys6]-LH-RH TFA | 1253.41 (free base) | 5 MG
[D-Lys6]-LH-RH TFA is a Luteinizing-hormone-releasing hormone (LHRH) analogue that acts as a GnRH receptor agonist. It inhibits the growth of experimental prostate cancer in rats.
- Acts as a GnRH receptor agonist
- Inhibits the growth of experimental prostate cancer in rats
Medchemexpress LLC Api137 TFA | 1428789-03-0 | 2291.71 | 1 MG
Api137 is an antimicrobial peptide designed to interfere with bacterial growth by inhibiting translation. It achieves this by trapping release factors on the 70S ribosome after the nascent polypeptide chain has been hydrolyzed, thereby preventing protein synthesis.
- Antimicrobial activity: effectively interferes with bacterial growth
- Translation inhibition: specific action on protein synthesis by targeting ribosomal release factors
- Research use only: intended for research purposes
- TFA form availability: available in a TFA (trifluoroacetate) form
Medchemexpress LLC TL033 | 2356230-22-1 | 1630.83 | 25 MG
TL033 is a chemical substance identified for laboratory use, including the manufacture of other substances. It is supplied as a solid and is intended for research purposes only by experienced personnel.
- Identified for laboratory chemical manufacturing
- Supplied as a solid
- Recommended storage at -20°C, protected from light
- Stable under recommended storage conditions
- For research use only
Medchemexpress LLC Norleual TFA | 6404-28-0 | >99.9% | 888.97 | 5 MG
Norleual TFA is an angiotensin (Ang) IV analog and a hepatocyte growth factor (HGF)/c-Met inhibitor with an IC50 of 3 pM. It also functions as an AT4 receptor antagonist and demonstrates potent antiangiogenic activities.
- Reduces HGF-dependent c-Met and Gab1 phosphorylation
- Attenuates HGF-initiated association between Gab1 and c-Met
- Inhibits HGF-dependent c-Met activation and downstream signaling
- Inhibits HGF-dependent signaling, proliferation, migration, and invasion
- Suppresses pulmonary colonization by B16-F10 murine melanoma cells
Medchemexpress LLC PKA RII peptide TFA | 99.7% | 2226.37 | 10 MG
PKA RII peptide TFA is a PKA substrate that, after being phosphorylated at the serine residue, can be used for the detection of calcineurin activity. It is for research use only.
- Solid appearance, white to off-white color.
- Sequence: Asp-Leu-Asp-Val-Pro-Ile-Pro-Gly-Arg-Phe-Asp-Arg-R-Val-Ser-Val-Ala-Ala-Glu.
- Sequence shortening: DLDVPIPGRFDRRVSVAAE.
- Store as powder at -80°C for 2 years or -20°C for 1 year.
- Store in solvent at -80°C for 6 months or -20°C for 1 month (sealed storage, away from moisture).
- Soluble in H2O at 25 mg/mL (11.23 mM, requires ultrasonic).
Medchemexpress LLC RSM3 TFA | 98.83% | 3049.66 | 5 MG
RSM3 TFA, a stapled peptide, is a METTL3-METTL14 inhibitor with a Kd of 3.10 μM. It inhibits tumor growth and induces cell apoptosis. RSM3 TFA can be used for the study of cancer.
- Inhibits tumor growth
- Induces cell apoptosis
- Used for the study of cancer
- Stapled peptide
- METTL3-METTL14 inhibitor
Medchemexpress LLC SAR441255 (TFA) | 99.9% | 4866.56 | 25 MG
SAR441255 TFA is a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist. It displays high potency with balanced activation of all three target receptors and shows positive acute glucoregulatory effects in diabetic obese monkeys.
- Potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist.
- Displays high potency with balanced activation of all three target receptors.
- Shows positive acute glucoregulatory effects in diabetic obese monkeys.
Medchemexpress LLC Veldoreotide TFA | 2126831-23-8 | 99.0% | 1237.33 | 1 MG
Veldoreotide (DG3173) TFA is a somatostatin analogue that binds to and activates somatostatin receptors (SSTR) 2, 4, and 5. It inhibits growth hormone (GH) secretion in adenomas and shows potential as a pain modulating agent. This product is for research use only.
- Binds to and activates SSTR 2, 4, and 5
- Inhibits growth hormone (GH) secretion
- Potential pain modulating agent
- Purity: 98.97%
- Appearance: White to off-white solid
- Soluble in H2O at 25 mg/mL (requires ultrasonic)
Medchemexpress LLC NN1177 (TFA) | 98.7% | 4570.07 (free base) | 25 MG
NN1177 TFA is a long-acting GLP-1/glucagon receptor co-agonist. It induces dose-dependent body weight loss in diet-induced obese mice. This product is for research use only.
- Long-acting GLP-1/glucagon receptor co-agonist
- Induces dose-dependent body weight loss in diet-induced obese mice
- Reduces CYP3A4 mRNA expression and activity in human hepatocytes
- Improves glucose tolerance in diet-induced obese mice
- Reduces liver fat and inflammatory biomarkers in NASH model mice
Medchemexpress LLC YKL-5-124 trifluoroacetate | 2748220-93-9 | 99.7% | 629.63 | C30H34F3N7O5 | 10 MM x 1 ML
YKL-5-124 TFA is the trifluoroacetate salt of a potent, selective, irreversible, covalent cyclin-dependent kinase 7 (CDK7) inhibitor. Supplied as a 10 mM solution in DMSO (1 mL), it is intended for research use in biochemical and cellular assays and is reported to induce cell-cycle arrest and inhibit E2F-driven gene expression while minimally affecting RNA polymerase II phosphorylation.
- Potent, selective CDK7 inhibition
- Irreversible covalent mechanism of action
- Supplied as a 10 mM solution in DMSO, 1 mL vial
- High purity suitable for biochemical and cellular studies
- Molecular formula and mass provided for identification
![eMolecules 1810069-99-8 | bis(2,2,2-trifluoroacetic acid);2-(2,2,2-trifluoroethyl)-2,6-diazaspiro[3.3]heptane | MFCD29037458 | 1g](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502158414.JPG-250.jpg)
eMolecules 1810069-99-8 | bis(2,2,2-trifluoroacetic acid);2-(2,2,2-trifluoroethyl)-2,6-diazaspiro[3.3]heptane | MFCD29037458 | 1g
Medchem Express | Azosemide | 10mg | 495799592 | HY-107321 | 27589-33-9 | MFCD00867321 | 370.830 | C12H11ClN6O2S2
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Medchemexpress LLC Ac-VDVAD-CHO (TFA) | 00-00-0 | 99.2% | 657.59 g·mol⁻¹ | C25H38F3N5O12 | 5 MG
Ac-VDVAD-CHO (TFA) is a peptide aldehyde inhibitor used in biochemical and cell-based research to block caspase-mediated proteolysis and investigate apoptosis pathways.
- Selective caspase-2 and caspase-3 inhibition (IC50 46 nM and 15 nM).
- TFA salt, supplied as a white to off-white solid.
- High purity (99.2%).
- Molecular weight 657.59 g·mol⁻¹; formula C25H38F3N5O12.
- Recommended storage: powder at -80°C (2 years) or -20°C (1 year).
- For research use only; not for human or clinical use.